Decoctions (5%, 20%, and 50% [w/v]) prepared from Peperomia pellucida, Andrographis paniculata and Hemigraphis reptans were tested for their mutagenicity, clastogenicity and antimutagenicity potential employing the methods of the Rec Assay, an in vitro test and the Micronucleus test, an in vivo test. Both the Rec Assay and the Micronucleus test indicate that the prepared decoctions do not possess DNA-damaging capacity nor do they possess constituent which may cause chromosome-breaking effects. These three herbal plants are therefore non-mutagenic and are safe as a medicinal. Furthermore, the results of the antimutagenicity tests have indicated that the decoctions reduce the formation of micronuclei on the bone marrow cells. This antimutagenicity/anticlastogenicity potential will thus strengthen its value as a medicinal. Since only one in vitro test and one in vivo test were made, it is highly recommended that other test systems be conducted, like the Pour Plate test (Ames test) and the Host-Mediated Assay.