This study reports on the identification and fluconazole susceptibility of 579 yeast which came from patients in 16 medical establishments throughout the Philippines in 1997-98. Speciation revealed the following yeasts with percent frequency of isolation: Candida albicans (49.6%); C. parapsilosis (17.2%); C. tropicalis (14.9%); C.glabrata (6.2%); C.pelliculosa (4.3%; C. krusei (2.4%); C. guilliermondii (1.9%); Trichosporon cutaneum (1.7%); Cryptococcus neoformans (0.9%); Candida famata (0.5%); C. lusitaniae (0.2%); and Saccharamyces cerevisiae (0.2%). Assays for fluconazole sensitivity revelaed that 94% were susceptible, 5% were dose-dependent sensitive and only 1% was resistant. All isolates of Candida albicans were susceptible (one isolate being dose-dependent sensitive) to fluconazole. The only yeasts that were resistant to fluconazole were Candida guillermondii, C. glabrata and C. parapsilosis.
To determine the clinically significant yeasts (genus and species) that cause disease in patients in the Philippines.2. To identify the yeast that are resistant to fluconazole.