A comparative open randomized study on the efficacy of Metronidazole and Penicillin in the treatment of tetanus was done. Fifty (50) cases were equally divided between the two groups. Patients on metronidazole had a significantly better clinical outcome and shorter duration of stay in the hospital. Twenty four (24) out of twenty five (25) patients or 96 on metronidazole had excellent results while only eighteen (18) out of twenty five (25) or 72 on penicillin had a similar result. It appears that metronidazole is more effective than penicillin.
The study aimed to validate the efficacy of metronidazole and to compare its efficacy against penicillin in the treatment of tetanus in an open randomized comparative clinical trial.