Twenty-five white rats (Rattus Norvegicus) were randomly distributed into five groups with 5 rats per group. The first group served as a negative control group and the rest were given Alloxan intraperitonially to induce a diabetogenic effect and treated with 0%, 50%, 75%, and 100% of the stock solutions respectively. Blood glucose determination using Hemoglucotest tapes with a Glucometer were made for 3 consecutive days to find out if the decoction had any lowering effects on blood glucose levels. The negative control maintained both its mean blood glucose level and mean weight during the treatment period. At a 0.05 level of significance, there was a significant difference in the mean blood glucose level between the positive group and the experimental group. However, there was no significant difference noted both in the mean blood glucose levels when different concentrations of Banaba decoction were used at different time intervals. There was also a significant difference in the mean weights among the treated group with those given 50% decoction the least and 100% decoction the greatest decrease respectively.
The study aimed to (1) verify the efficacy of banaba leaf decoction as a substitute for insulin in the treatment of alloxan-induced hyperglycemic rats; (2) determine the relative efficacy of different concentrations of banaba leaf docoction in lowering blood glucose level.