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Submitted: 21 July 2016 Modified: 21 July 2016
HERDIN Record #: NCR-JAFES-16072111494113

A 58-year-old Malay female with underlying diabetes mellitus, presented with chronic skin lesions, associated with weight loss and anemia. There were erosive, scaling skin lesions over the extremities, gluteal region and perioral area. Skin biopsy histopathological examination revealed Necrolytic Migratory Erythema (NME). A CT scan of the abdomen revealed a pancreatic neck and body tumor with possible liver metastases. She was successfully treated with subcutaneous somatostatin and underwent distal pancreatectomy with wedge resection of liver nodule.


 

Publication Type
Journal
Publication Sub Type
Case report
Title
Journal of the ASEAN Federation of Endocrine Societies
Frequency
Semi-Annual
Publication Date
May 2016
Volume
31
Issue
1
Page(s)
50-54
LocationLocation CodeAvailable FormatAvailability
http://www.asean-endocrinejournal.org (632) 6373162 Fulltext External Link (View)
1. Sachithanandan, S , Tzen, C Y, Raman, K , Colao, A . "Neuroendocrine tumor symposium (GIST & NETs: A Multidisciplinary Journey)" Oncology Tribune , 2, November 2010. Retrieved from: http://www.mems.my/file_dir/20344153334d6c5f4d5d075.pdf
2. Sachithanandan, S , Tzen, C Y, Raman, K , Colao, A . "Neuroendocrine tumor symposium (GIST & NETs: A Multidisciplinary Journey)" Oncology Tribune , 2, November 2010. Retrieved from: http://www.mems.my/file_dir/20344153334d6c5f4d5d075.pdf
3. Sachithanandan, S , Tzen, C Y, Raman, K , Colao, A . "Neuroendocrine tumor symposium (GIST & NETs: A Multidisciplinary Journey)" Oncology Tribune , 2, November 2010. Retrieved from: http://www.mems.my/file_dir/20344153334d6c5f4d5d075.pdf
4. Alkemade, J A, van Tongeren, J H, van Haelst, U J. "Delayed diagnosis of glucagonoma syndrome" Clin Exp Dermatol 24(6): 455-7, 1999. Retrieved from: http://dx.doi.org/10.1046/j.1365-2230.1999.00531.x
5. Alkemade, J A, van Tongeren, J H, van Haelst, U J. "Delayed diagnosis of glucagonoma syndrome" Clin Exp Dermatol 24(6): 455-7, 1999. Retrieved from: http://dx.doi.org/10.1046/j.1365-2230.1999.00531.x
6. Alkemade, J A, van Tongeren, J H, van Haelst, U J. "Delayed diagnosis of glucagonoma syndrome" Clin Exp Dermatol 24(6): 455-7, 1999. Retrieved from: http://dx.doi.org/10.1046/j.1365-2230.1999.00531.x
7. Wermers, R A, Fatourechi, V , Wynne, A G, Kvols, L K, Lloyd, R V. "The glucagonoma syndrome: Clinical and pathologic features in 21 patients" Medicine (Baltimore) 75(2): 53-63, 1996. Retrieved from: http://dx.doi.org/10.1097/00005792-199603000-00002
8. Wermers, R A, Fatourechi, V , Wynne, A G, Kvols, L K, Lloyd, R V. "The glucagonoma syndrome: Clinical and pathologic features in 21 patients" Medicine (Baltimore) 75(2): 53-63, 1996. Retrieved from: http://dx.doi.org/10.1097/00005792-199603000-00002
9. Wermers, R A, Fatourechi, V , Wynne, A G, Kvols, L K, Lloyd, R V. "The glucagonoma syndrome: Clinical and pathologic features in 21 patients" Medicine (Baltimore) 75(2): 53-63, 1996. Retrieved from: http://dx.doi.org/10.1097/00005792-199603000-00002
10. DeLellis , R A, ed. Pathology and genetics of tumours of endocrine organs. IARC WHO Classification of tumours 2004. (3rd ed, Vo)
11. DeLellis , R A, ed. Pathology and genetics of tumours of endocrine organs. IARC WHO Classification of tumours 2004. (3rd ed, Vo)
12. DeLellis , R A, ed. Pathology and genetics of tumours of endocrine organs. IARC WHO Classification of tumours 2004. (3rd ed, Vo)
13. Butte, J M, Montero, P H, Solar, A , Torres, J . "Cervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case" Surgery Today 38(12): 1137-43, 2008. Retrieved from: http://dx.doi.org/10.1007/s00595-008-3763-1
14. Butte, J M, Montero, P H, Solar, A , Torres, J . "Cervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case" Surgery Today 38(12): 1137-43, 2008. Retrieved from: http://dx.doi.org/10.1007/s00595-008-3763-1
15. Butte, J M, Montero, P H, Solar, A , Torres, J . "Cervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case" Surgery Today 38(12): 1137-43, 2008. Retrieved from: http://dx.doi.org/10.1007/s00595-008-3763-1
16. Eldor, R , Glaser, B , Fraenkel, M , Doviner, V . "Glucagonoma and the glucagonoma syndrome-cumulative experience with an elusive endocrine tumour" Clin Endocrinol 74(5): 593-98, 2011. Retrieved from: http://dx.doi.org/10.1111/j.1365-2265.2011.03967.x
17. Eldor, R , Glaser, B , Fraenkel, M , Doviner, V . "Glucagonoma and the glucagonoma syndrome-cumulative experience with an elusive endocrine tumour" Clin Endocrinol 74(5): 593-98, 2011. Retrieved from: http://dx.doi.org/10.1111/j.1365-2265.2011.03967.x
18. Eldor, R , Glaser, B , Fraenkel, M , Doviner, V . "Glucagonoma and the glucagonoma syndrome-cumulative experience with an elusive endocrine tumour" Clin Endocrinol 74(5): 593-98, 2011. Retrieved from: http://dx.doi.org/10.1111/j.1365-2265.2011.03967.x
19. Shi, W , Liao, W , Mei, X , Xiao, Q . "Necrolytic migratory erythema associated with glucagonoma syndrome" J Clin Oncol 28(20): e329-e331, 2010. Retrieved from: http://dx.doi.org/10.1200/JCO.2009.25.7113
20. Shi, W , Liao, W , Mei, X , Xiao, Q . "Necrolytic migratory erythema associated with glucagonoma syndrome" J Clin Oncol 28(20): e329-e331, 2010. Retrieved from: http://dx.doi.org/10.1200/JCO.2009.25.7113
21. Shi, W , Liao, W , Mei, X , Xiao, Q . "Necrolytic migratory erythema associated with glucagonoma syndrome" J Clin Oncol 28(20): e329-e331, 2010. Retrieved from: http://dx.doi.org/10.1200/JCO.2009.25.7113
22. Stacpoole, P W. "The glucagonoma syndrome: Clinical features, diagnosis, and treatment" Endocr Rev 2(3): 347-61, 1981. Retrieved from: http://dx.doi.org/ http://dx.doi.org/10.1210/edrv-2-3-347
23. Stacpoole, P W. "The glucagonoma syndrome: Clinical features, diagnosis, and treatment" Endocr Rev 2(3): 347-61, 1981. Retrieved from: http://dx.doi.org/ http://dx.doi.org/10.1210/edrv-2-3-347
24. Stacpoole, P W. "The glucagonoma syndrome: Clinical features, diagnosis, and treatment" Endocr Rev 2(3): 347-61, 1981. Retrieved from: http://dx.doi.org/ http://dx.doi.org/10.1210/edrv-2-3-347
25. Koike, N , Hatori, T , Imaizumi, T , Harada, N . "Malignant glucagonoma of the pancreas diagnosed through anemia and diabetes mellitus" J Hepatobiliary Pancreat Surg 10(1): 101-5, 2003. Retrieved from: http://dx.doi.org/ 10.1007/s10534-002-0791-y
26. Koike, N , Hatori, T , Imaizumi, T , Harada, N . "Malignant glucagonoma of the pancreas diagnosed through anemia and diabetes mellitus" J Hepatobiliary Pancreat Surg 10(1): 101-5, 2003. Retrieved from: http://dx.doi.org/ 10.1007/s10534-002-0791-y
27. Koike, N , Hatori, T , Imaizumi, T , Harada, N . "Malignant glucagonoma of the pancreas diagnosed through anemia and diabetes mellitus" J Hepatobiliary Pancreat Surg 10(1): 101-5, 2003. Retrieved from: http://dx.doi.org/ 10.1007/s10534-002-0791-y
28. Fenkci, S M, Yaylali, G F, Sermez, Y , Akdam, H . "Malign cystic glucagonoma presented with diabetic ketoacidosis: Case report with an update" Endocr Relat Cancer 12(2): 449-54, 2005. Retrieved from: http://dx.doi.org/ 10.1677/erc.1.00957
29. Fenkci, S M, Yaylali, G F, Sermez, Y , Akdam, H . "Malign cystic glucagonoma presented with diabetic ketoacidosis: Case report with an update" Endocr Relat Cancer 12(2): 449-54, 2005. Retrieved from: http://dx.doi.org/ 10.1677/erc.1.00957
30. Fenkci, S M, Yaylali, G F, Sermez, Y , Akdam, H . "Malign cystic glucagonoma presented with diabetic ketoacidosis: Case report with an update" Endocr Relat Cancer 12(2): 449-54, 2005. Retrieved from: http://dx.doi.org/ 10.1677/erc.1.00957
31. McGevna, L , McFadden, D , Ritvo, J . "Glucagonoma-associated neuropsychiatric and affective symptoms: Diagnostic dilemmas raised by paraneoplastic phenomena" Psychosomatics 50(5): 548-9, 2009. Retrieved from: http://dx.doi.org/ 10.1176/appi.psy.50.5.548
32. McGevna, L , McFadden, D , Ritvo, J . "Glucagonoma-associated neuropsychiatric and affective symptoms: Diagnostic dilemmas raised by paraneoplastic phenomena" Psychosomatics 50(5): 548-9, 2009. Retrieved from: http://dx.doi.org/ 10.1176/appi.psy.50.5.548
33. McGevna, L , McFadden, D , Ritvo, J . "Glucagonoma-associated neuropsychiatric and affective symptoms: Diagnostic dilemmas raised by paraneoplastic phenomena" Psychosomatics 50(5): 548-9, 2009. Retrieved from: http://dx.doi.org/ 10.1176/appi.psy.50.5.548
34. Mallinson, C N, Bloom, S R, Warin, A P, Salmon, P R, Cox, B . "A glucagonoma syndrome" The Lancet 305(7871): 1-5, 1974. Retrieved from: http://dx.doi.org/10.1016/S0140-6736(74)91343-9
35. Mallinson, C N, Bloom, S R, Warin, A P, Salmon, P R, Cox, B . "A glucagonoma syndrome" The Lancet 305(7871): 1-5, 1974. Retrieved from: http://dx.doi.org/10.1016/S0140-6736(74)91343-9
36. Mallinson, C N, Bloom, S R, Warin, A P, Salmon, P R, Cox, B . "A glucagonoma syndrome" The Lancet 305(7871): 1-5, 1974. Retrieved from: http://dx.doi.org/10.1016/S0140-6736(74)91343-9
37. van Beek, A P, de Haas, E R, Van Vloten, W A. "The glucagonoma syndrome and necrolytic migratory erythema: A clinical review" Eur J Endocrinol 151(5): 531-7, 2004. Retrieved from: http://dx.doi.org/10.1530/eje.0.1510531
38. van Beek, A P, de Haas, E R, Van Vloten, W A. "The glucagonoma syndrome and necrolytic migratory erythema: A clinical review" Eur J Endocrinol 151(5): 531-7, 2004. Retrieved from: http://dx.doi.org/10.1530/eje.0.1510531
39. van Beek, A P, de Haas, E R, Van Vloten, W A. "The glucagonoma syndrome and necrolytic migratory erythema: A clinical review" Eur J Endocrinol 151(5): 531-7, 2004. Retrieved from: http://dx.doi.org/10.1530/eje.0.1510531
40. Remes-Troche , J M, García-de-Acevedo, B , Zuñiga-Varga, J . "Necrolytic migratory erythema: A cutaneous clue to glucagonoma syndrome" J Eur Acad Dermatol Venereol 18(5): 591-5, 2004. Retrieved from: http://dx.doi.org/ 10.1111/j.1468-3083.2004.00981.x
41. Remes-Troche , J M, García-de-Acevedo, B , Zuñiga-Varga, J . "Necrolytic migratory erythema: A cutaneous clue to glucagonoma syndrome" J Eur Acad Dermatol Venereol 18(5): 591-5, 2004. Retrieved from: http://dx.doi.org/ 10.1111/j.1468-3083.2004.00981.x
42. Remes-Troche , J M, García-de-Acevedo, B , Zuñiga-Varga, J . "Necrolytic migratory erythema: A cutaneous clue to glucagonoma syndrome" J Eur Acad Dermatol Venereol 18(5): 591-5, 2004. Retrieved from: http://dx.doi.org/ 10.1111/j.1468-3083.2004.00981.x
43. Teixeira , R C, Nico, M M, Ghideti, A C. "Necrolytic migratory erythema associated with glucagonoma: A report of 2 cases" Clinics 63(2): 267-70, 2008. Retrieved from: http://dx.doi.org/10.1590/S1807-59322008000200016
44. Teixeira , R C, Nico, M M, Ghideti, A C. "Necrolytic migratory erythema associated with glucagonoma: A report of 2 cases" Clinics 63(2): 267-70, 2008. Retrieved from: http://dx.doi.org/10.1590/S1807-59322008000200016
45. Teixeira , R C, Nico, M M, Ghideti, A C. "Necrolytic migratory erythema associated with glucagonoma: A report of 2 cases" Clinics 63(2): 267-70, 2008. Retrieved from: http://dx.doi.org/10.1590/S1807-59322008000200016
46. Kitamura, Y , Sato, M , Hatamochi, A , Yamazaki, S . "Necrolytic migratory erythema without glucagonoma associated with hepatitis B" Eur J Dermatol 15(1): 49-51, 2005
47. Kitamura, Y , Sato, M , Hatamochi, A , Yamazaki, S . "Necrolytic migratory erythema without glucagonoma associated with hepatitis B" Eur J Dermatol 15(1): 49-51, 2005
48. Kitamura, Y , Sato, M , Hatamochi, A , Yamazaki, S . "Necrolytic migratory erythema without glucagonoma associated with hepatitis B" Eur J Dermatol 15(1): 49-51, 2005
49. Delaporte , E , Catteau, B , Piette, F . "Necrolytic migratory erythema-like eruption in zinc deficiency associated with alcoholic liver disease" Br J Dermatol 137(6): 1027-8, 1997. Retrieved from: http://dx.doi.org/10.1111/j.1365-2133.1997.tb01583.x
50. Delaporte , E , Catteau, B , Piette, F . "Necrolytic migratory erythema-like eruption in zinc deficiency associated with alcoholic liver disease" Br J Dermatol 137(6): 1027-8, 1997. Retrieved from: http://dx.doi.org/10.1111/j.1365-2133.1997.tb01583.x
51. Delaporte , E , Catteau, B , Piette, F . "Necrolytic migratory erythema-like eruption in zinc deficiency associated with alcoholic liver disease" Br J Dermatol 137(6): 1027-8, 1997. Retrieved from: http://dx.doi.org/10.1111/j.1365-2133.1997.tb01583.x
52. Castro, P G, de León, A M, Trancón, J G. "Glucagonoma syndrome: A case report" J Med Case Rep 5, 402, 2011. Retrieved from: http://dx.doi.org/10.1186/1752-1947-5-402
53. Castro, P G, de León, A M, Trancón, J G. "Glucagonoma syndrome: A case report" J Med Case Rep 5, 402, 2011. Retrieved from: http://dx.doi.org/10.1186/1752-1947-5-402
54. Castro, P G, de León, A M, Trancón, J G. "Glucagonoma syndrome: A case report" J Med Case Rep 5, 402, 2011. Retrieved from: http://dx.doi.org/10.1186/1752-1947-5-402
55. O, H L, Conlon, K C. "Pancreatic neuroendocrine tumours" Eur J Surg Oncol 34(3): 324-32, 2008. Retrieved from: http://dx.doi.org/10.1016/j.ejso.2007.07.209
56. O, H L, Conlon, K C. "Pancreatic neuroendocrine tumours" Eur J Surg Oncol 34(3): 324-32, 2008. Retrieved from: http://dx.doi.org/10.1016/j.ejso.2007.07.209
57. O, H L, Conlon, K C. "Pancreatic neuroendocrine tumours" Eur J Surg Oncol 34(3): 324-32, 2008. Retrieved from: http://dx.doi.org/10.1016/j.ejso.2007.07.209
58. Kindmark, H , Sundin, A , Granberg, D , Dunder, K , Skogseid, B , Janson, E T. "Endocrine pancreatic tumors with glucagon hypersecretion: A retrospective study of 23 cases during 20 years" Medical Oncology 24(3): 330-7, 2007. Retrieved from: http://dx.doi.org/10.1007/s12032-007-0011-2
59. Kindmark, H , Sundin, A , Granberg, D , Dunder, K , Skogseid, B , Janson, E T. "Endocrine pancreatic tumors with glucagon hypersecretion: A retrospective study of 23 cases during 20 years" Medical Oncology 24(3): 330-7, 2007. Retrieved from: http://dx.doi.org/10.1007/s12032-007-0011-2
60. Kindmark, H , Sundin, A , Granberg, D , Dunder, K , Skogseid, B , Janson, E T. "Endocrine pancreatic tumors with glucagon hypersecretion: A retrospective study of 23 cases during 20 years" Medical Oncology 24(3): 330-7, 2007. Retrieved from: http://dx.doi.org/10.1007/s12032-007-0011-2
61. "The chromogranin-secretogranin family" New Engl J Med 348(25): 2579-80, . Retrieved from: http://dx.doi.org/10.1056/NEJM200306193482519
62. "The chromogranin-secretogranin family" New Engl J Med 348(25): 2579-80, . Retrieved from: http://dx.doi.org/10.1056/NEJM200306193482519
63. "The chromogranin-secretogranin family" New Engl J Med 348(25): 2579-80, . Retrieved from: http://dx.doi.org/10.1056/NEJM200306193482519
64. "The glucagonoma syndrome: A review of its features and discussion of new perspectives" Am J Med Sci 321(5): 306-20, . Retrieved from: http://dx.doi.org/ 10.1097/00000441-200105000-00003
65. "The glucagonoma syndrome: A review of its features and discussion of new perspectives" Am J Med Sci 321(5): 306-20, . Retrieved from: http://dx.doi.org/ 10.1097/00000441-200105000-00003
66. "The glucagonoma syndrome: A review of its features and discussion of new perspectives" Am J Med Sci 321(5): 306-20, . Retrieved from: http://dx.doi.org/ 10.1097/00000441-200105000-00003
67. "Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors" Arch Surg 138(8): 859-66, . Retrieved from: http://dx.doi.org/10.1001/archsurg.138.8.859
68. "Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors" Arch Surg 138(8): 859-66, . Retrieved from: http://dx.doi.org/10.1001/archsurg.138.8.859
69. "Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors" Arch Surg 138(8): 859-66, . Retrieved from: http://dx.doi.org/10.1001/archsurg.138.8.859
70. "Islet cell tumors" The Gastroenterologist 5(3): 213-32,
71. "Islet cell tumors" The Gastroenterologist 5(3): 213-32,
72. "Islet cell tumors" The Gastroenterologist 5(3): 213-32,
73. "Histologic variation in the skin lesions of the glucagonoma syndrome" Am J Surg Pathol 10(7): 445-53,
74. "Histologic variation in the skin lesions of the glucagonoma syndrome" Am J Surg Pathol 10(7): 445-53,
75. "Histologic variation in the skin lesions of the glucagonoma syndrome" Am J Surg Pathol 10(7): 445-53,
76. "Insulinoma and glucagonoma" Semin Oncol 14(3): 253-62,
77. "Insulinoma and glucagonoma" Semin Oncol 14(3): 253-62,
78. "Insulinoma and glucagonoma" Semin Oncol 14(3): 253-62,
79. "Necrolytic migratory erythema without glucagonoma in patients with liver disease" J Am Acad Dermatol 34(6): 1092, . Retrieved from: http://dx.doi.org/10.1016/S0190-9622(96)90299-6
80. "Necrolytic migratory erythema without glucagonoma in patients with liver disease" J Am Acad Dermatol 34(6): 1092, . Retrieved from: http://dx.doi.org/10.1016/S0190-9622(96)90299-6
81. "Necrolytic migratory erythema without glucagonoma in patients with liver disease" J Am Acad Dermatol 34(6): 1092, . Retrieved from: http://dx.doi.org/10.1016/S0190-9622(96)90299-6
82. "Is glucagonoma of the pancreas a curable disease?" Int J Pancreatol 29(3): 155-62, . Retrieved from: http://dx.doi.org/ 10.1385/IJGC:29:3:155
83. "Is glucagonoma of the pancreas a curable disease?" Int J Pancreatol 29(3): 155-62, . Retrieved from: http://dx.doi.org/ 10.1385/IJGC:29:3:155
84. "Is glucagonoma of the pancreas a curable disease?" Int J Pancreatol 29(3): 155-62, . Retrieved from: http://dx.doi.org/ 10.1385/IJGC:29:3:155
85. "Clinical experience in diagnosis and treatment of glucagonoma" Zhonghua wai ke za zhi. Chinese 47(5): 333-6,
86. "Clinical experience in diagnosis and treatment of glucagonoma" Zhonghua wai ke za zhi. Chinese 47(5): 333-6,
87. "Clinical experience in diagnosis and treatment of glucagonoma" Zhonghua wai ke za zhi. Chinese 47(5): 333-6,
88. "Surgical treatment of endocrine pancreatic tumours" Neuroendocrinology 80(Suppl 1): 62-6, . Retrieved from: http://dx.doi.org/10.1159/000080744
89. "Surgical treatment of endocrine pancreatic tumours" Neuroendocrinology 80(Suppl 1): 62-6, . Retrieved from: http://dx.doi.org/10.1159/000080744
90. "Surgical treatment of endocrine pancreatic tumours" Neuroendocrinology 80(Suppl 1): 62-6, . Retrieved from: http://dx.doi.org/10.1159/000080744
91. "Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group" J Clin Oncol 27(28): 4656-63, . Retrieved from: http://dx.doi.org/10.1200/JCO.2009.22.8510
92. "Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group" J Clin Oncol 27(28): 4656-63, . Retrieved from: http://dx.doi.org/10.1200/JCO.2009.22.8510
93. "Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group" J Clin Oncol 27(28): 4656-63, . Retrieved from: http://dx.doi.org/10.1200/JCO.2009.22.8510
94. "Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome" Clin Endocrinol 57(6): 827-31, . Retrieved from: http://dx.doi.org/10.1046/j.1365-2265.2002.01660.x
95. "Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome" Clin Endocrinol 57(6): 827-31, . Retrieved from: http://dx.doi.org/10.1046/j.1365-2265.2002.01660.x
96. "Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome" Clin Endocrinol 57(6): 827-31, . Retrieved from: http://dx.doi.org/10.1046/j.1365-2265.2002.01660.x
97. Kheir, S M, Omura, E F, Grizzle, W . "Neuroendocrine tumors" J Natl Compr Canc Netw 10(6): 724-64,
98. "Neuroendocrine tumors" J Natl Compr Canc Netw 10(6): 724-64,
99. "Neuroendocrine tumors" J Natl Compr Canc Netw 10(6): 724-64,

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