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HERDIN Record #: PCHRD17020812443790 Submitted: 08 February 2017 Modified: 29 March 2017

Mixed germ cell tumor in Androgen insensitivity syndrome: A case report.

Mary Grace M. Villafuerte,
Agnes  L. Soriano-Estrella

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Androgen insensitivity syndrome (AIS) is a disorder of sexual development characterized by a female phenotype with a 46 XY karyotype. Most patients present with primary amenorrhea; however,1.1% of patients present with an inguinal mass. Most commonly, seminoma arising from the gonads are found.                                                                                This report represents the case of a 15 year-old female looking adolescent who initially presented with an abdominopelvic mass. A diagnosis of AIS was made based on the physical examination findings, endocrine profiling, imaging studies and karyotyping. She underwent cytoscopy, exploratory laparotomy,adhesiolysis, tumor debulking, frozen section, bowel run, repair of serosal tear, Jackson-Pratt drain insertion, bilateral percutaneous nephrostomy under combined spinal and epidural anesthesia. Histopathologic examination of the excised mass revealed a mixed germ cell tumor. This paper will discuss the diagnostic approach as well as the management and prognosis of patients with AIS associated with mixed germ cell tumor.

Publication Type
Publication Sub Type
Case report
Philippine Journal of Obstetrics and Gynecology
Publication Date
October-December 2016
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Box No. 52-A Fulltext Print Format (Request Document)
1. Villafuerte, Mary Grace M., Soriano-Estrella, Agnes L.. "Mixed germ cell tumor in Androgen insensitivity syndrome: A case report" Philippine Journal of Obstetrics and Gynecology 40(4): 23-28, October 2016-December 2016

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