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Submitted: 18 August 2017 Modified: 18 August 2017
HERDIN Record #: NCR-JAFES-17081817425421

Efficacy of magnesium supplementation on glycemic control in type 2 diabetes patients: a meta-analysis.

Elizabeth Paz-Pacheco

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Methodology. We searched MEDLINE/PubMed, Cochrane Library, Acta Medica Philippina, Health Research and Development Information Network (HERDIN) and references of reviewed journals from 1966 to July 2015 using the following search terms: "magnesium" OR "magnesium supplementation" OR "magnesium replacement", AND randomized controlled trial AND diabetes OR diabetes mellitus OR non-insulin dependent diabetes mellitus OR diabetic OR diab* (with MeSH, where available). Studies were retrieved and rated independently using the standards provided by The Cochrane Collaboration. High quality trials were included in a systematic review and meta-analysis.


Results. Of the 689 records screened, 10 studies were included in the qualitative synthesis and 7 studies in the meta-analysis. Pooled data showed a non-significant trend towards improvement in glycemic control in the magnesium-treated group (mean difference -0.19, CI -0.58 to 0.21). There was a stronger but still non-significant trend in T2DM patients with hypomagnesemia (mean difference -1.16, CI -2.92 to 0.6).


Conclusion. Routine magnesium supplementation for improvement in glycemic control in T2DM patients cannot be recommended based on data from included studies in this meta-analysis.

To evaluate if magnesium supplementation, in addition to standard therapy, improves fasting blood sugar (FBS) and/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM) compared to placebo or other comparator.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Journal of the ASEAN Federation of Endocrine Societies
Frequency
Semi-Annual
Publication Date
May-October 2017
Volume
32
Issue
1
Page(s)
38-45

Objectives

To evaluate if magnesium supplementation, in addition to standard therapy, improves fasting blood sugar (FBS) and/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM) compared to placebo or other comparator.

LocationLocation CodeAvailable FormatAvailability
http://www.asean-endocrinejournal.org (632) 6373162 Fulltext External Link (View)
1. IDF Diabetes Atlas, 7th ed.. Brussels, Belgium: International Diabetes Federation, 2015. . Retrieved from: http://www.diabetesatlas.org/
2. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC, United States of America: National Academies Press (US), 1997.
3. Yajnik, CS , Smith, RF , Hockaday, TD . "Fasting plasma magnesium concentrations and glucose disposal in diabetes" Br Med J (Clin Res Ed) 288, 1032-4, 1984
4. Nadler, JL , Buchanan, T , Natarajan, R . "Magnesium deficiency produces insulin resistance and increased thromboxane synthesis" Hypertension 21(6 Pt 2): 1024-9, 1993

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