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HERDIN Record #: R07-USC-18092709141661 Submitted: 27 September 2018 Modified: 11 December 2018

Hypoglycemic effect of the extract from the whole plant of Tawa-tawa, Euphorbia hirta Linn. (1926) on alloxan-induced male albino mice.

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In this study, the hypoglycemic activity of the extract of the whole plant, Euphorbia hirta was obtained by decoction. The positive control used was a five milligram Glipzide tablet, dissolved in enough quantity of distilled water to make 100 ml with the strength of 0.05mg/ml. The negative control used was distilled water. Hyperglycemia was induced on male albino mice using 35mg/ml or 3.5% alloxan solution which was orally administered using a tuberculin syringe. Hyperglycemic blood glucose levels were administered 48 hours after induction of alloxan. Then the three doses of the Euphorbia hirta extract and the Group P (positive control) with a dose of 0.20 ml per 30 gram mouse were administered to the designated mouse, twice a day for four days. Blood sugar levels were taken on the 10th day and last day of treatments using a glucometer. Three trials with three replicates were performed in the experiment. Statistical Analysis through One-Way ANOVA and Tukey's HSD Test showed that the three doses of the Euphorbia hirta extract have a hypoglycemic activity against the alloxan-induced hyperglycemic albino mice but differences in percent reduction between each doses and the positive control proved to be significant.

Publication Type
Thesis Degree
Publication Date
March 2012
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / J336c Fulltext Print Format (Ask the Information Officer)
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