Report an error   


HERDIN Record #: R07-USC-18092709141661 Submitted: 27 September 2018 Modified: 11 December 2018

Hypoglycemic effect of the extract from the whole plant of Tawa-tawa, Euphorbia hirta Linn. (1926) on alloxan-induced male albino mice.

See More

In this study, the hypoglycemic activity of the extract of the whole plant, Euphorbia hirta was obtained by decoction. The positive control used was a five milligram Glipzide tablet, dissolved in enough quantity of distilled water to make 100 ml with the strength of 0.05mg/ml. The negative control used was distilled water. Hyperglycemia was induced on male albino mice using 35mg/ml or 3.5% alloxan solution which was orally administered using a tuberculin syringe. Hyperglycemic blood glucose levels were administered 48 hours after induction of alloxan. Then the three doses of the Euphorbia hirta extract and the Group P (positive control) with a dose of 0.20 ml per 30 gram mouse were administered to the designated mouse, twice a day for four days. Blood sugar levels were taken on the 10th day and last day of treatments using a glucometer. Three trials with three replicates were performed in the experiment. Statistical Analysis through One-Way ANOVA and Tukey's HSD Test showed that the three doses of the Euphorbia hirta extract have a hypoglycemic activity against the alloxan-induced hyperglycemic albino mice but differences in percent reduction between each doses and the positive control proved to be significant.

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Pharmacy
Publication Date
March 2012
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / J336c Fulltext Print Format (Ask the Information Officer)
1. Abdallah , S , Ahmad, A T, Batieha, A , Ajlouni, K . "Diabetes mellitus: The leading cause of haemodialysis in Jordan" Eastern Mediterranean health journal 13, 803-9, 2017
2. Ayoola, G A, Coker, H.A. B, Adesegun, S A, Adepoju-Bello, A A, Obaweya, K , Ezennia, E C, Atangbayila, T O. "Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria" Tropical Journal of Pharmaceutical Research 7(3): 1019-1024, 2008
3. Gamez, M J, Jimenez, J , Risco, S , Zarzuelo, A . "Hypoglycemic activity in various species of the genus Lavandula. Part 1: Lavandula stoechas L. and Lavandula multifida L. Pharmazie" 42, 706-7, 1987
4. Hoffimann, Y , Murakmi, N , Ji, H , Abreu, Pedro , Zhang, S . "Antimalarial Flavonol Glycosides from Euphorbia hirta" 45(4): 278-281, 2007
5. Joseph, B , Jini , D . "Insight into the hypoglycemic effect of traditional Indian herbs used in the treatment of diabetes" Research Journal of Medicinal Plant 5, 352-376, 2011
6. Kumar, S , Malhotra, R , Kumar, D . "Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities" Pharmacognosy Review 4, 58-61, 2010
7. Lenzen, S . "The mechanisms of alloxan and streptozotocin induced diabetes" Diabetological 51, 216-226, 2008
8. Mishra, A , Wiling, A. . "Studies on Ayurvedic crude Drugs for the cure of urinary tract stones" International Journal of Mendel 18(1-2): 41-42, 2001
9. Romula, G , Yadav, S , Vats , V . "Medicinal plants of India with antidiabetic potential" Journal of Ethnopharmacology 81, 81-100, 2002
10. Satyanarayana, S , Rajesakhar , J , Sushruta, K , Srinivas, N . "Evaluation of the Blood-Glucose Reducing Effects of Aqueous Extracts of the Selected umbelliferous Fruits Used in Culinary Practices" Tropical Journal of Pharmaceutical Research 5(2): 613-617, 2006
11. Sethi, J , Sood, S , Seth, S , Talwar, A . "Evaluation of hypoglycemic and antioxidant effect of Ocimum sanctum" Indian Journal of Clinical Biochemistry 19(2): 152-155, 2004
12. Sharma, V K, Kumar, S , Patel , H J, Hugar, S . "Hypoglycemic Activity of Ficus glomerata in Alloxan-induced Diabetic Rats" International Journal of Pharmaceutical Sciences Review and Research 1(2): 18-22, 2004
13. Zeleny, I M, Cabrera, W A, Meneses, K B, Rivera, V R. Philippine Journal of Sciences 127, 261-266, 1998
14. Aligui, S K, Bhardwah, R , Lakhanpal, T N. Ethnic Indian Plants in cure of diabetes Jodhpur, India: Scientific Publishers, 2005. 64-5.
15. Davidson, S , Haslett, C , Chilvers, E R, Boon, N A, College, N R, Hunter, J A. “Diabetes Mellitus” . In: The Principles and Practice of Medicine. 19th ed Philadelphia: Churchill Livingstone, 2005. 641-682.
16. Evan, . Selection, Preparation and Pharmacological evaluation of Plant Material New York: John Wiley and Sons Ltd, 1996. 283-285.
17. Harborne, J B. Phytochemical methods. London Chapman and Hall Ltd, 1973. 49-188.
18. Harris, M , Zimmet, P . Classification of diabetes mellitus and other categories of glucose intolerance.. International Textbook of Diabetes Mellitus 2nd Edition Chichester: John Wiley and Sons Ltd, 1997. 9-23.
19. Hewitt, R . Dorland’s Illustrated Medical Dictionary 22nd Edition Philadelphia and London: W.B. Saunders Company, 1951.
20. Knevel, A M, DiGangi, F E. Jenkin’s Quantitative Pharmaceutical Chemistry New York : McGraw-Hill Book Company, 1977. 230-1.
21. Laurence, D R, Bacharach, A L . Evaluation of Drug Activities and Pharmacometrics Volume 1 London and New York: Academic Press, 1993. 160-161 .
22. Trease, G E, Evans, W C. Pharmacognosy 11th Edition Brailliar Tridel Can. Macmillian publishers, 1989.
23. Gale, E . "Possible link between insulin glargine and cancer prompts urgent call for more research" Diabetologia : The Journal of EASD , 2009
24. WHO, . Diabetes mellitus: Report of a WHO study group. 1985.
25. Buot, K A, Malubay, M . The Hypoglycemic Activity of the Juice of the Leaves Brassica oleracea Linn. Variety Capitata (Cabbage) on Alloxan-Induced Hyprglycemic mice. 2003. (BS) University of San Carlos,
26. Castilo, W A, Villacorte, O . The Hypoglycemic effect of the pure juice of marine macroalgae, CAULERPA LENTILIFERA J. GARDH, KAPPAPHYCUS ALVAREZII DOTY AND SARGASSUM POLYCYSTUM J. AGARDH on male albino mice. 2016. (BS) University of San Carlos,
33. (). . Retrieved from: http://www.umm.edu/ency/article/000313.htm
 

Copyright © One Window Project 2018. All rights reserved.