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Submitted: 27 September 2018 Modified: 11 December 2018
HERDIN Record #: R07-USC-18092711453335

Sedative activity of the crude extractive of Annona muricata Linn., 1753 (Guyabano) leaves on male albino mice.

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                The sedative activity of the crude extractive of Annonamuricata leaves were investigated using male albino mice. The extractive was prepared from the fresh leaves of Annonamuricata using decoction. The extractive was administered to the test animal in three different doses. The study aimed to determine the dose that exhibited the highest sedative activity at 15 minutes after administration by the 4 parameters (Coordinated pavement test, Traction test, Loss of Screen Grip, Video Recording System)


The 1ml/20g dose exhibited the greatest sedative activity compared to the other doses of the Annonamuricata extractive. 0.5ml/20g dose showed intermediate response to the positive control. In contrast, the 0.1ml/20g mice dose of the Annonamuricata leaf extractive showed less or no response to the parameters.


                In the phytochemical screening using test tube method: terpenes, tannins and reducing sugars were found present in Annonamuricata leaf extractive which might be the possible causes of the sedative activity.Terpenes have shown to possess metrological effects, altering the production of neurotransmitters serotonin and dopamine and acting like a cannabinoid receptor agonist (Spalding, 2011). Reducing sugars act by inhibiting Orexin, which is a brain chemical which helps in making a person awake (Lehrer, 2008). Tannins are used in alcohols which can cause more sedative activity due to its astringent effect (Richard, 2006).

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Pharmacy
Publication Date
March 2013
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / D393d Fulltext Print Format (Ask the Information Officer)
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